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oai:drum.lib.umd.edu:1903/197672017-09-14T02:33:02Zcom_1903_7125com_1903_1633com_1903_2col_1903_7129col_1903_3

Dyerà!o, Typhanye Stennett, Christina Digital Repository at the University of Maryland University of Maryland (College Park, Md.) Epidemiology and Biostatistics 2017-09-13T05:31:59Z 2017-09-13T05:31:59Z 2017 https://doi.org/10.13016/M2R20RW98 http://hdl.handle.net/1903/19767 It is well documented that women with robust, Lactobacillus-dominated vaginal microbiotas are less likely to develop a range of adverse reproductive health outcomes. The birthing process is thought to be a critical event in the initial seeding, or colonization, of the human microbiome, and the transfer of microbiota from mother to baby during delivery is associated with long-term health. We recruited 88 adult women to a cross-sectional study to evaluate the relationship between their vaginal microbiota and the mode of their birth (self-reported as vaginal delivery or Cesarean section (C-section)). In a multivariable analysis, women who had a less protective, low-Lactobacillus community state type had 3-fold increased odds of having been born via C-section, indicating that C-section is related to vaginal dysbiosis in adulthood (adjusted OR: 3.73, p=0.01, 95% CI: 1.08-12.77). Although the cross-sectional analysis does not account for fluctuations in microbial composition, the significant point estimate suggests that birth mode may play a role in vaginal seeding and colonization outcomes in adult women. en MODE OF BIRTH AND VAGINAL MICROBIOTA IN REPRODUCTIVE-AGE WOMEN Thesis Epidemiology birth mode c-section vaginal microbiota open.access