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oai:drum.lib.umd.edu:1903/104752016-03-29T04:41:10Zcom_1903_2219com_1903_1654com_1903_2col_1903_2751col_1903_3

Bentley, William E Parmar, Anupreet Digital Repository at the University of Maryland University of Maryland (College Park, Md.) Chemical Engineering 2010-07-03T05:38:32Z 2010-07-03T05:38:32Z 2010 http://hdl.handle.net/1903/10475 A comprehensive model for calculating pH and conductivity values for a buffer solution added to the eluate of a cation exchange column at Bayer Healthcare has been developed. Bayer Healthcare's Berkeley facility manufacturess Kogenate - a drug for Hemophilia. This project was carried out at one of the intermediate purification steps of Kogenate, where the pH and conductivity of a buffer solution added to a chromatographic column's eluate has to be critically adjusted. Currently this process is done manually and requires two operators. In order to reduce the manual labor as well as improve accuracy, an automation model was developed using feedback control and Bayer's pH and conductivity predicting empirical correlations. AUTOMATION MODEL FOR pH AND CONDUCTIVITY ADJUSTMENT FOR A CATION EXCHANGE COLUMN ELUATE BUFFER Thesis Chemistry, General open.access